Matrix-embedded cells control osteoclast formation
نویسندگان
چکیده
منابع مشابه
Aseptic Loosening Osteoclast Osteoblast Macrophage HUMAN OSTEOBLASTIC CELLS SUPPORT OSTEOCLAST FORMATION FROM ARTHROPLASTY-DERIVED MACROPHAGES
Introduction: A predominant histological feature of periprosthetic tissue surrounding aseptically loose implant components is the presence of a prominent foreign body macrophage response to prosthesis derived wear. A number of potent bone resorbing mediators have been identified in periprosthetic tissue from around loose prostheses and these mediators have been shown to be released from wear pa...
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In a previous study, using co-cultures of embryonic bone rudiments stripped of periosteum, and mononuclear phagocytes of various sources, we found that multinucleated mineral-resorbing osteoclasts developed in vitro from radiosensitive mouse bone marrow mononuclear phagocytes (BMMP). (Burger, E. H., J. W. M. van der Meer, J. S. van de Gevel, C. W. Thesingh, and R. van Furth, 1982, J. Exp. Med. ...
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Multinucleated giant cells derive from fusion of precursor cells of the macrophage lineage. It has been proposed that the purinoreceptor P2X(7) is involved in this fusion process. Prolonged exposure of macrophages to ATP, the ligand for P2X(7), induces the formation of plasma membrane pores and eventual cell death. We took advantage of this cytolytic property to select RAW 264.7 (RAW) cells tha...
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چکیده مقدمه: ماده خارج سلولی به عنوان بخش مهم ریز محیطMicroenvironment)(، نقش اساسی در نگهداری وضعیت تمایز دارد. در بررسی‌های گذشته، این اثر در برخی سلول‌ها از جمله سلول‌های پوششی لوله رحم و یا رحم مطالعه شده است. در این پژوهش‌ها، برای حفظ تمایز سلول ، علاوه بر ماده خارج سلولی عوامل دیگر‌ی مانند هورمون‌ها، فاکتورهای رشد و سلول‌های داربستی نیز بکار رفته است ولی فر...
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objective: genes involved in bone and tissue remodelling in the vertebrates include matrix metalloproteinase-9 (mmp-9), receptor activator of necrosis factor κ-β (rank), cathepsin-k (ctsk) and tartrate-resistant acid phosphatase (tracp). we examine whether these markers are expressed in cells of zebrafish embryos of 1-5 days post fertilization. we also examine adult scales, which are known to c...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2011
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.2448